|
Enantiomeric separation of cyclopropane derivatives on a polysaccharide-based chiral stationary phase [An article from: Analytica Chimica Acta] | ![Enantiomeric separation of cyclopropane derivatives on a polysaccharide-based chiral stationary phase [An article from: Analytica Chimica Acta]](http://ecx.images-amazon.com/images/I/415FBN4EPVL._SL160_.jpg)
 enlarge | Authors: A. Ghanem, H. Hoenen, P. Muller, H.y. Aboul-enein
Publisher: Elsevier
Buy New: $10.95
Format: Html
Media: Digital
| |
| Editorial Reviews:
Product Description
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
The enantioseparation of a set of new cyclopropanes derived from Meldrum's acid, dimethyl malonate, (silanoxyvinyl)-diazoacetates and 3,3,3-trifluoro-2-diazopropionate has been achieved on cellulose tris(3,5-dimethylphenylcarbamate) Chiralcel OD coated on 10@mm silica-gel as chiral stationary phase in high-performance liquid chromatography (HPLC). The HPLC was equipped with a sensitive optical rotation detector for monitoring the optical activity of the racemic and enantioenriched cyclopropanes prepared via the Rh(II)-catalyzed asymmetric intermolecular cyclopropanations. The mobile phase was a mixture of n-hexane-2-propanol (90:10, or 99:1, v/v) with a flow-rate of 0.3ml/min. The UV detector was set at 254nm. The advantages of the liquid over the gas chromatographic analysis of the cyclopropanes are demonstrated by a comparative study of both methods. The methods provide an easy and direct determination of the enantiomeric excesses of the cyclopropanes.
|
|
|
Powered by Associate-O-Matic
| |
top