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Capillary electrophoresis analysis of gabapentin and vigabatrin in pharmaceutical preparations as ofloxacin derivatives [An article from: Analytica Chimica Acta] | ![Capillary electrophoresis analysis of gabapentin and vigabatrin in pharmaceutical preparations as ofloxacin derivatives [An article from: Analytica Chimica Acta]](http://ecx.images-amazon.com/images/I/415FBN4EPVL._SL160_.jpg)
 enlarge | Authors: F.m. Lin, H.s. Kou, S.m. Wu, S.h. Chen, H.l. Wu
Publisher: Elsevier
Buy New: $8.95
Format: Html
Media: Digital
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Product Description
This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.
Description:
Gabapentin (GBP) and vigabatrin (VGB) are widely used anticonvulsants. In structure, they are amino carboxylic compounds, which lack practical chromophoric groups for detection by absorption spectrophotometry. Derivatization of gabapentin and vigabatrin with chromophoric ofloxacin acyl chloride (OAC) was performed and the resulting OAC derivatives can be analyzed by simple capillary zone electrophoresis (CZE) with UV detection (300nm). The detection limit (S/N = 3, injection 3s) of the method for the gabapentin or vigabatrin was 5@mM. Application of the method to the analysis of gabapentin and vigabatrin in pharmaceutical preparations proved simple and feasible. The precision (relative standard deviation) and accuracy (relative error) of the method for intra- and interday analyses of both drugs, in pharmaceuticals, were below 3.1 and 4.8%, respectively.
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